Poor stem cell harvest may not always be related to poor mobilization: lessons gained from a mobilization study in beta-thalassemia major patients
2017
BACKGROUND
Hematopoietic stem cell mobilization and leukapheresis in adult beta-thalassemia patients have been recently optimized in the context of clinical trials for obtaining hematopoietic stem cells for thalassemia gene therapy. In some patients, however, CD34+ cell yield was poor despite successful mobilization and the modification of apheresis settings was mandatory for harvest rescue.
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