Hybrid Materials Consisting of Hydroxyapatite and Bio-based Polymers Used as Scaffolds for Bone Tissue Engineering

Large bone defects require fabricated bone constructs that consist of three main components: an artificial extracellular matrix scaffold, stem cells with the potential to differentiate into osteoblasts, and bioactive substances, such as osteoinductive growth factors to direct the growth and differentiation of cells toward osteogenic lineage within the scaffold.