Long-acting bioactive composition based on chitosan and taxifolin

Chitosan-based hydrogel containing antioxidant dihydroquercetin is developed. The optimal concentration of a cross-linking agent making it possible to obtain viscous fluid chitosan hydrogels capable of protractedly producing dihydroquercetin is found. During hydrogel formation and its storage, 86% of dihydroquercetin remains in the initial form, and production of no more than 14% of thermal oxidation products is observed. At the same time, the original content of the flavonoid in the hydrogel is shown to be 5 times greater than its solubility in water; the dihydroquercetin isolation from the hydrogel is 4 times slower than from a chitosan solution. Adaptogenic activity of hydrogel was demonstrated under hypobaric hypoxia conditions in vivo orally applied to experimental animals.