Different Effects of Ketoconazole on the Stereoselective First- Pass Metabolism of R/S-Verapamil in the Intestine and the Liver: Important for the Mechanistic Understanding of First-Pass Drug-Drug Interactions

Helena Anna Thörn,Mikael Hedeland,Ulf Bondesson,Lars Knutson,Mohammed Yasin,Paul A. Dickinson,Hans Lennernäs

Different Effects of Ketoconazole on the Stereoselective First- Pass Metabolism of R/S-Verapamil in the Intestine and the Liver: Important for the Mechanistic Understanding of First-Pass Drug-Drug Interactions

2009

Helena Anna Thörn
Mikael Hedeland
Ulf Bondesson
Lars Knutson
Mohammed Yasin
Paul A. Dickinson
Hans Lennernäs

In this acute study a pig jejunal intestinal perfusion model with multiple plasma sampling sites and three different administration routes was used to investigate the quantitative contribution of t ...

Keywords:

Drug interaction
Endocrinology
Drug
Biochemistry
Internal medicine
Pharmaceutical sciences
Ketoconazole
Pharmacology
First pass effect
Chemistry
Perfusion
Verapamil
Pharmacokinetics
Metabolism

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