Surface Plasmon Resonance Microscopy (SPRM)

As a label-free visualization tool, surface plasmon resonance (SPR) reflectance imaging can characterize near-field fluidic transport properties within 100 nm from the solid surface. The key idea is that the SPR reflectance intensity varies with the near-field refractive index (RI) of the test fluid, which in turn depends on the micro- and nano-fluidic scalar properties, such as concentrations, temperatures, and phases.