A Randomized Trial of a Binocular iPad Game Versus Part-Time Patching in Children Aged 13 to 16 Years With Amblyopia

Purpose To compare visual acuity (VA) improvement in teenagers with amblyopia treated with a binocular iPad game vs part-time patching. Methods One hundred participants aged 13 to Results Mean amblyopic eye VA improved from baseline by 3.5 letters (2-sided 95% confidence interval [CI]: 1.3–5.7 letters) in the binocular group and by 6.5 letters (2-sided 95% CI: 4.4–8.5 letters) in the patching group. After adjusting for baseline VA, the difference between the binocular and patching groups was −2.7 letters (95% CI: −5.7 to 0.3 letters, P  = .082) or 0.5 lines, favoring patching. In the binocular group, treatment adherence data from the iPad device indicated that only 13% of participants completed >75% of prescribed treatment. Conclusions In teenagers aged 13 to