Novel Approach to Clinico-Neuroradiological Correlation and Prognostication in Cerebral Venous Sinus Thrombosis (P6.226)

OBJECTIVE: To identify the clinical differences in Cerebral Venous Sinus Thrombosis(CVST) depending upon the anatomical site of obstruction. BACKGROUND: CVST has a varying cluster of presentation in each group namely superficial versus deep sinuses, isolated versus combined sinuses and isolated paired versus unpaired sinuses. DESIGN/METHODS: Clinical manifestations in each group were retrospectively studied among 90 consecutive patients of CVST confirmed by magnetic resonance venogram and the prognostic indicators were correlated with the outcome (assessed by modified ranking scale). RESULTS: Headache [71(87.7[percnt]),p 40yrs [OR=3.6, 95[percnt]CI=1.2-10.8,p<0.01], motor weakness [OR=9.2, 95[percnt]CI=3.4-25.2,p<0.001], superior sagittal sinus thrombosis with/without other sinuses [OR=3.8, 95[percnt]CI=1-15.5,p<0.05] and low GCS [OR=6.0, 95[percnt]CI=3.3-10.7,p<0.001] contributed significantly to poor outcome. 8(21.6[percnt]) of those with isolated unpaired sinus involvement had poor outcome compared to 2(13.3[percnt]) with isolated paired sinus involvement CONCLUSIONS: Significant clinical differences were observed among the three groups studied. Thrombosis of isolated unpaired sinuses, multiple sinuses and deep veins had poor prognosis. Study Supported by: None Disclosure: Dr. Kalaimani has nothing to disclose. Dr. Nagarajan has nothing to disclose. Dr. Balakrishnan has nothing to disclose. Dr. Kesavamurthy has nothing to disclose. Dr. Lakshmi Narasimhan has nothing to disclose. Dr. Elangovan has nothing to disclose. Dr. Vellaichamy has nothing to disclose.