Instability of C154Y variant of aldo-keto reductase 1C3

Satoshi Endo,Sayaka Takada,Ryo Honda,Kathrin Muller,Jochen H. Weishaupt,Peter M. Andersen,Albert C. Ludolph,Yuji O. Kamatari,Toshiyuki Matsunaga,Kazuo Kuwata,Ossama El-Kabbani,Akira Ikari

Instability of C154Y variant of aldo-keto reductase 1C3

2017

Satoshi Endo
Sayaka Takada
Ryo Honda
Kathrin Muller
Jochen H. Weishaupt
Peter M. Andersen
Albert C. Ludolph
Yuji O. Kamatari
Toshiyuki Matsunaga
Kazuo Kuwata
Ossama El-Kabbani
Akira Ikari

Aldo-keto reductase (AKR) 1C3 is a cytosolic enzyme that metabolizes steroids, prostaglandins, toxic aldehydes and drugs. Recently, some nonsynonymous single nucleotide polymorphisms of AKR1C3 have ...

Keywords:

Molecular biology
Enzyme
Biochemistry
Reductase
Nonsynonymous substitution
SOD1
Instability
Chemistry
Single-nucleotide polymorphism
Aldo-keto reductase
Drug metabolism
Cytosol
Carbonyl reduction

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