Medial HOXA genes demarcate haematopoietic stem cell fate during human development

Diana R. Dou,Vincenzo Calvanese,Maria I. Sierra,Andrew Nguyen,Arazin Minasian,Pamela Saarikoski,Rajkumar Sasidharan,Christina M. Ramirez,Jerome A. Zack,Zoran Galic,Hanna Mikkola

Medial HOXA genes demarcate haematopoietic stem cell fate during human development

2016

Diana R. Dou
Vincenzo Calvanese
Maria I. Sierra
Andrew Nguyen
Arazin Minasian
Pamela Saarikoski
Rajkumar Sasidharan
Christina M. Ramirez
Jerome A. Zack
Zoran Galic
Hanna Mikkola

Mikkola and colleagues show that medial HOXA gene expression, induced by retinoic acid signalling, marks the establishment of the definitive HSC fate and controls HSC identity and function.

Keywords:

Gene expression profiling
Adult stem cell
Cellular differentiation
Cell biology
Multipotent Stem Cell
Stem cell
Haematopoiesis
Retinoic acid
Stem cell lineage database
Biology
Progenitor cell
Embryonic stem cell
Induced pluripotent stem cell

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