Значение некоторых иммуноморфологических факторов для определения прогноза аденокарциномы легкого

The aim of this study was to search tumor expression of thymidylate synthetase and some other immunomorphological markers and to determine their prognostic role for pulmonary adenocarcinoma. Methods. Histological and immunohistochemical study of pulmonary adenocarcinoma has been conducted using several markers such as thymidylate synthetase, Ki67, p53, Bcl2, Bax. Results. Thymidylate synthetase and cellular prolif eration activity marker Ki67 were revealed in 100 % of cases; p53, Bcl2 and Bax were revealed in 48 %, 7.9 % and 6.3 %, respectively. The results demonstrated a tendency to decrease 3year eventfree survival by 14 % (p = 0.1007) in patients with high thymidylate synthetase expression in comparison to patients with low expression. Conclusion . Thymidylate synthetase could be used as a prognostic factor of pulmonary adenocarcinoma course.