Editorial: Animal Models of Stress - Current Knowledge and Potential Directions

Finding new therapies and new antidepressant agents is of high clinical priority given that many cases of depressive disorder do not respond to conventional monoaminergic antidepressants such as selective serotonin reuptake inhibitors, tricyclic antidepressants, and monoamine oxidase inhibitors The authors demonstrated that electroacupuncture and fluoxetine, a second-generation antidepressant categorized as a selective serotonin reuptake inhibitor (Perez-Caballero et al , 2014), regulate the expression of key proteins in the calmodulin kinase (CAMK) signaling pathway, which are related to depression in the hippocampi of rats (Takemoto-Kimura et al , 2017;Xie et al , 2019) In a paper on “Short- and Long-Term Repeated Forced Swim Stress Induce Depressive-Like Phenotype in Mice: Effectiveness of 3-[(4-chlorophenyl)selanyl]-1-methyl-1H-indole,” our research group found that in the context of depression induced by stress and the antidepressant-like effect of novel molecules, 3-[(4-chlorophenyl)selanyl]-1-methyl-1H-indole (CMI), a synthetic organoselenium compound, is effective in abolishing the depressive-like behavior induced by repeated forced swim stress (FSS) in male mice [ ]it recalls that the cholinergic system is composed of cholinergic neurons that use the acetylcholine neurotransmitter