Research progress on stem cell therapy for pathological skin scars

The current clinical treatment effect of hypertrophic scar is not satisfactory. Stem cells are expected to bring new ideas to treatment because of their ability to self-renew and differentiate. This article introduces some scar stem cells of different sources and their advantages and disadvantages, including various mesenchymal stem cells, human amniotic epithelial cells, embryonic stem cells and induced pluripotent stem cells etc. Besides, this article points out that the key points of breakthrough in stem cell therapy are the regulation of secreted protein, the proper using time of stem cells, the transmission and maintenance of stemness, and the selection of appropriate stem cell population for patients, etc. and provide a reference for the development of pathological scar stem cell therapy. Key words: Keloid; Stem cells; Epithelial cells; Amnion; Hypertrophic Scar