Temperature sensitive gel sustained-release oral agent with paracetamol

The invention discloses a temperature sensitive gel sustained-release oral agent with a paracetamol, and relates to the technical field of pharmaceutic preparation. A carrier in the oral agent provided by the invention convenient for feeding includes paracetamol serving as an active ingredient and xyloglucan or a mixture of xyloglucan and another polysaccharide, wherein another polysaccharide is pectin, chitosan, algal polysaccharides or gellan gum. According to the invention, a polymer three-dimensional gel net structure formed by the polysaccharide is used for establishing a sustained-release system combined with clinical pathology so as to obtain the temperature sensitive gel sustained-release oral agent with the paracetamol; the temperature range for sol-gel change is 35-37 DEG C which is close to body temperature, so the oral agent is particularly suitable for old people, infants and people who have difficulty in swallowing, and has obvious efficacy. The temperature sensitive gel sustained-release oral agent disclosed by the invention has obvious analgesic and antipyretic effects, is convenient for administration and free of toxic and side effects, and the drug action can last for a long time.