Characterization of the nociceptin receptor (ORL-1) agonist, Ro64-6198, in tests of anxiety across multiple species

Geoffrey B. Varty,Lynn A. Hyde,Robert A. Hodgson,Sherry X. Lu,Martha F. McCool,Tatiana M. Kazdoba,R. A. Del Vecchio,Donald H. Guthrie,Annamarie Pond,Michael Grzelak,Xiaoying Xu,Walter A. Korfmacher,Deen Tulshian,Eric M. Parker,Guy A. Higgins

Characterization of the nociceptin receptor (ORL-1) agonist, Ro64-6198, in tests of anxiety across multiple species

2005

Geoffrey B. Varty
Lynn A. Hyde
Robert A. Hodgson
Sherry X. Lu
Martha F. McCool
Tatiana M. Kazdoba
R. A. Del Vecchio
Donald H. Guthrie
Annamarie Pond
Michael Grzelak
Xiaoying Xu
Walter A. Korfmacher
Deen Tulshian
Eric M. Parker
Guy A. Higgins

Rationale Previous studies have demonstrated behaviors indicative of anxiolysis in rats pretreated with the nociceptin receptor (opioid receptor like-1, ORL-1) agonist, Ro64-6198.

Keywords:

Internal medicine
Anesthesia
Endocrinology
Agonist
Test anxiety
Inverse agonist
Nociceptin receptor
Anxiety
Opioid receptor
Psychology
Ro64-6198
Guinea pig
Receptor

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