Immunological effects of methylprednisolone pulse treatment in progressive multiple sclerosis.

Abstract Objective To investigate the effect of monthly oral methylprednisolone pulse treatment in progressive MS. Methods 30 progressive MS patients were treated with oral methylprednisolone every month. Peripheral blood mononuclear cells were analyzed by flow cytometry. Results Out of 102 leukocyte phenotypes investigated, 25 changed at nominal significance from baseline to week 12 (p  Conclusion Methylprednisolone pulse treatment has some effects on circulating immune cells but does not modulate markers of Th17 and TFH cell activity in progressive MS.