Effects of a Local Focus of Granulation Tissue Formed in the Bone Marrow Cavity on Reparative Osteogenesis

Russian G. A. Ilizarov Scientific Center for Restorative Traumatology and Orthopaedics, Ministry of Health of Russian Federation, Kurgan, Russia. Address for correspondence: irianov@mail.ru. Yu. M. Ir’yanov The development and experimental morphological validation of biomedical technologies for stimulation of reparative osteogenesis is an urgent problem, especially in adult and elderly patients [2,3]. Cell technologies now work mainly with multipotent mesenchymal stromal cells (MMSC) from the bone marrow, fatty tissue, umbilical, placental, and peripheral blood [6,8,9]. Granulation tissue forming in the bone marrow cavity during bone healing has never been regarded as a potential source of MMSC. On the other hand, it is an interesting object, because bone marrow cells are precursors of the majority of macrophages, fi broblasts, osteoblasts, and endotheliocytes in bone regenerate. We studied the morphology of reparative osteogenesis during healing of a tibial bone fracture under conditions of transosseous osteosynthesis and formation of local granulation tissue foci in the bone marrow cavity.