The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity
2017
SUV4-20 members mediate the di- and trimethylation of lysine 20 on histone H4. A chemical screen led to the identification of A-196 as a potent and selective inhibitor of SUV4-20 that decreases H4K20 methylation and alters DNA damage response.
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