AMPK regulates energy expenditure by modulating NAD + metabolism and SIRT1 activity

AMP-activated protein kinase (AMPK) is shown to transcriptionally regulate genes involved in controlling energy metabolism in skeletal muscle by acting together with the NAD+-dependent deacetylase SIRT1. AMPK enhances SIRT1 activity by increasing cellular NAD+ levels, resulting in the deacetylation and activation of the SIRT1 downstream target PGC-1α.