Obesity-driven disruption of haematopoiesis and the bone marrow niche

In this Review, the authors explore the interactions between obesity, haematopoiesis and the immune system through systemic effects and changes to the primary haematopoietic environment—the bone marrow niche. They also discuss the effects of adipocytes and adiposity on haematopoietic stem cell and progenitor cell populations, with the goal of understanding how obesity might compromise the core haematopoietic system.