Hematopoietic stem cell transplantation without irradiation
2009
Long-term engraftment of hematopoietic stem cells into the bone marrow of a recipient depends on immunological compatibility between donor and host, or ablation of the host's immune system by irradiation. A 'universal recipient' mouse model now shows that mice that lack T, B and NK cells and bear mutations in the tyrosine kinase Kit accept any donor HSC without irradiation.
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