An Assessment of Modafinil for Vestibular and Aviation-Related Effects

Abstract : The goal of this study was to provide data concerning both the efficacy and the safe-to-fly dosage of a relatively unique compound, modafinil. Previous studies have indicated that modafinil holds promise as an effective wake-promoting agent for military personnel assigned to sustained operations without the common side effects associated with amphetamine-like substances. The present research was conducted to examine whether 200 or 400 mg doses of modafinil have any effect upon human vestibular functioning at night, to verify its cognitive enhancement capabilities during a short-term, sleep-loss setting, and to document the presence/absence of subjective symptoms. Other measures were investigated for possible effects of over-confidence or dehydration.