A leak pathway for luminal protons in endosomes drives oncogenic signalling in glioblastoma

Glioblastoma multiforme is the most common and aggressive form of primary brain tumour, and in 50% of cases EFGR is mutated, amplified or upregulated. Here the authors show that NHE9 controls the amount of EGFR at the membrane surface of brain tumour-initiating stem cells by affecting the luminal pH of sorting endosomes.