Copper‐Catalyzed Remote C‐H Sulfonylation of 8‐Aminoquinoline Amides with Arylsulfonyl Hydrazides

An efficient copper-catalyzed remote C-5 sulfonylation of 8-aminoquinoline amides using stable and readily available arylsulfonyl hydrazides has been developed. In the presence of 10 mol-% Cu(OAc)2 as a catalyst and Ag2CO3 as an oxidant, a wide range of 8-aminoquinoline amides underwent sulfonylation with arylsulfonyl hydrazides to generate structurally diverse aryl sulfones in moderate to good yields.