8-Aminoquinoline

8-Aminoquinoline is a bicyclic heterocyclic amine. It is structurally analogous to 8-hydroxyquinoline. The two nitrogen atoms are ideally situated to form complexes with metal ions.PrimaquinePamaquineTafenoquine 8-Aminoquinoline is a bicyclic heterocyclic amine. It is structurally analogous to 8-hydroxyquinoline. The two nitrogen atoms are ideally situated to form complexes with metal ions. The derivatives primaquine, tafenoquine and pamaquine have been tested for anti-malaria activity. . Primaquine is still used routinely worldwide as part of the treatment of Plasmodium vivax and Plasmodium ovale malaria. Tafenoquine is currently in Phase III clinical trials and is not yet available to prescribe. Tetradentate ligands based on 8-Aminoquinoline with a − ( CH 2 ) n − NH − ( CH 2 ) m − NH 2 {displaystyle {ce {-(CH2)n-NH-(CH2)m-NH2}}} side chain have been synthesized. These ligands have a specificity for copper against zinc as high as 1000..