Quinoline triciclic derivatives. Design, synthesis and preliminary in vitro and in silico antiviral activity against flaviviridae family of three new classes of viruses-encoded RNA-dependent RNA polymerase (RdRp) inhibitors

As part of our antiviral research program, we have recently synthesized and tested in vitro several series of new angular and linear heterocyclic systems against representatives of ssRNA+ viruses [ Bovine Viral Diarrhea Virus (BVDV), Yellow Fever Virus (YFV), Coxsackie B2 (CVB-2), Polio [Sb-1] and Human Immunodeficiency Virus (HIV-1)], ssRNA viruses [ Respiratory Syncytial Virus (RSV) and Vesicular Stomatitis Virus (VSV)], dsRNA viruses [ Reovirus (Reo-1)], and of DNA viruses [ Vaccinia Virus (VV)] [1,2].