RevealingLectin–Sugar Interactions with aSingle Au@Ag Nanocube
2019
An
individual nanoparticle-based plasmonic nanotechnology was used
for real-time monitoring of lectin–sugar interactions, which
could be designed as novel plasmonic nanobiosensors for the detection
of trace concanavalin A (ConA) with high sensitivity and selectivity.
The localized surface plasmon resonance (LSPR) spectra of Au@Ag nanocubes
(NCs) are linearly shifted to a long wavelength with an increasing
concentration of ConA. In fact, each Au@Ag NC can act as a nanobiosensor
for the quantified detection of trace ConA, which enables the miniaturization
of the biosensor system to nanoscale. Furthermore, the results demonstrated
the perfect biosensing ability with the dual channel of dark-field
microscopy images and LSPR spectra. We expect that this nanobiosensor
system can provide an alternative important method for monitoring
the specific binding of lectin–sugar at a single nanoparticle
surface.
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