QSAR of inhibition of classical pathway of complement activation by dicarboxylic acids

Svetlana Bureeva,Julian Andia-Pravdivy,Anna M. Bichucher,Dmitry A. Orishchenko,Alexander Kaplun

QSAR of inhibition of classical pathway of complement activation by dicarboxylic acids

2005

Svetlana Bureeva
Julian Andia-Pravdivy
Anna M. Bichucher
Dmitry A. Orishchenko
Alexander Kaplun

The influence of distance between charges, hydrophobic and electronic parameters of aliphatic and aromatic dicarboxylic acids on the complement-inhibiting activity (CIA) has been ascertained using the QSAR method.

Keywords:

Classical complement pathway
Dicarboxylic acid
Organic chemistry
Quantitative structure–activity relationship
Biochemistry
Chemistry
Complement system
Stereochemistry

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