Multimodal Monitoring of Human Brain Organoids Implanted in Mice Using Transparent Microelectrodes

Martin Thunemann,Madison Wilson,Francesca Puppo,Donald P. Pizzo,Hannah Rickner,Emma Bortz,Abed AlFatah Mansour,Benjamin Wolozin,Xue Han,Fred H. Gage,Alysson R. Muotri,Duygu Kuzum,Anna Devor

Multimodal Monitoring of Human Brain Organoids Implanted in Mice Using Transparent Microelectrodes

2021

Martin Thunemann
Madison Wilson
Francesca Puppo
Donald P. Pizzo
Hannah Rickner
Emma Bortz
Abed AlFatah Mansour
Benjamin Wolozin
Xue Han
Fred H. Gage
Alysson R. Muotri
Duygu Kuzum
Anna Devor

We present an in vivo platform merging stem cell technology, two-photon imaging, and electrophysiology with transparent graphene microelectrodes for longitudinal interrogation of human brain organoids implanted in the cortex of immunodeficient mice.

Keywords:

Biomedical engineering
Human brain
cortex
Electrophysiology
Stem cell
In vivo
Microelectrode
Green fluorescent protein
Organoid
Chemistry

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

Citations