High serum resistin levels are associated with peripheral artery disease in the hypertensive patients

Abstract Background Hypertension is a risk factor for peripheral arterial disease (PAD). Subjects with PAD are at increased risk of future cardiovascular (CV) events. Resistin is involved in the pathological processes of CV diseases. The aim of this study is to investigate whether resistin level is correlated with PAD in hypertensive patients. Methods One hundred and twenty-four hypertensive patients were enrolled in this study. Ankle-brachial index (ABI) values were measured using the automated oscillometric method. An ABI value  Results Eighteen hypertensive patients (14.5%) were included in the low ABI group. Hypertensive patients in the low ABI group were older ( p  = 0.043) and had higher serum creatinine ( p p  = 0.013), and resistin ( p p  = 0.002) than patients in the normal ABI group. After the adjustment for factors that were significantly associated with PAD on multivariate logistic regression analysis, serum resistin (odds ratio [OR], 1.176; 95% confidence interval [CI], 1.028–1.345; p  = 0.018) was also an independent predictor of PAD in hypertensive patients. Conclusions A high serum resistin level is an independent predictor of PAD in hypertensive patients.