Intrinsic resistance to selumetinib, a selective inhibitor of MEK1/2, by cAMP-dependent protein kinase A activation in human lung and colorectal cancer cells

Teresa Troiani,Loredana Vecchione,Erika Martinelli,Anna Capasso,Sarah Costantino,Loreta Pia Ciuffreda,Floriana Morgillo,Donata Vitagliano,Elena D’Aiuto,R. De Palma,Sabine Tejpar,E. Van Cutsem,M. De Lorenzi,Michele Caraglia,Liberato Berrino,Fortunato Ciardiello

Intrinsic resistance to selumetinib, a selective inhibitor of MEK1/2, by cAMP-dependent protein kinase A activation in human lung and colorectal cancer cells

2012

Teresa Troiani
Loredana Vecchione
Erika Martinelli
Anna Capasso
Sarah Costantino
Loreta Pia Ciuffreda
Floriana Morgillo
Donata Vitagliano
Elena D’Aiuto
R. De Palma
Sabine Tejpar
E. Van Cutsem
M. De Lorenzi
Michele Caraglia
Liberato Berrino
Fortunato Ciardiello

Intrinsic resistance to selumetinib, a selective inhibitor of MEK1/2, by cAMP-dependent protein kinase A activation in human lung and colorectal cancer cells

Keywords:

Mitogen-activated protein kinase kinase
Protein kinase A
Cell cycle
Colorectal cancer
Selumetinib
Pathology
Immunology
Medicine
Cell growth
Cancer research
Enzyme activator
Apoptosis
gene mutation

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