Substoichiometric inhibition of transthyretin misfolding by immune-targeting sparsely populated misfolding intermediates: a potential diagnostic and therapeutic for TTR amyloidoses.

Natalie J. Galant,Antoinette Bugyei-Twum,Rishi Rakhit,Patrick Walsh,Simon Sharpe,Pharhad Eli Arslan,Per Westermark,Jeffrey N. Higaki,Ronald Torres,Jose R. Tapia,Avijit Chakrabartty

Substoichiometric inhibition of transthyretin misfolding by immune-targeting sparsely populated misfolding intermediates: a potential diagnostic and therapeutic for TTR amyloidoses.

2016

Natalie J. Galant
Antoinette Bugyei-Twum
Rishi Rakhit
Patrick Walsh
Simon Sharpe
Pharhad Eli Arslan
Per Westermark
Jeffrey N. Higaki
Ronald Torres
Jose R. Tapia
Avijit Chakrabartty

Wild-type and mutant transthyretin (TTR) can misfold and deposit in the heart, peripheral nerves, and other sites causing amyloid disease. Pharmacological chaperones, Tafamidis (R) and diflunisal, ...

Keywords:

Chaperone (protein)
Diflunisal
Protein folding
Transthyretin
Amyloid disease
Cancer research
Amyloidosis
Bioinformatics
Immune Targeting
Medicine
Tafamidis
Fibrillogenesis
Biochemistry
Native state
Epitope
Fibril

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