Activation of ERK and Mutual Regulation of Stat3 and SP1 Contribute to Inhibition of PDK1 Expression by Atractylenolide-1 in Human Lung Cancer Cells

Qian Xiao,Fang Zheng,JingJing Wu,Qing Tang,Wei Wang,Swei Sunny Hann

Activation of ERK and Mutual Regulation of Stat3 and SP1 Contribute to Inhibition of PDK1 Expression by Atractylenolide-1 in Human Lung Cancer Cells

2017

Qian Xiao
Fang Zheng
JingJing Wu
Qing Tang
Wei Wang
Swei Sunny Hann

Background/Aims: Atractylodes macrocephula Koidz is an important ingredient in traditional Chinese herbs. One major bioactive compound, atractylenolide-1 (ATL-1),

Keywords:

Cancer cell
Atractylodes
Bioactive compound
Ingredient
Human lung
Diabetes mellitus
MAPK/ERK pathway
STAT3
Cancer research
Biology
Gene expression
Phosphorylation
Biochemistry
Cell growth
Sp1 transcription factor
Cell biology
Kinase
Cell cycle

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