Hematopoietic stem cells depend upon Gsα-mediated signalling to engraft bone marrow

The guanine-nucleotide-binding protein stimulatory α subunit (Gαs) is necessary for the homing and engraftment of haematopoietic stem and progenitor cells to bone marrow, as demonstrated by its disruption in adult mice deficient in Gαs. Conversely, pharmacological activators of Gαs enhance homing and engraftment in vivo, suggesting a potential pharmacological target to improve transplantation efficiency.