Longitudinal cognitive assessment in patients with primary CNS lymphoma treated with induction chemotherapy followed by reduced-dose whole-brain radiotherapy or autologous stem cell transplantation
2019
Introduction
The standard treatment for primary central nervous system lymphoma (PCNSL) involves induction methotrexate-based chemotherapy with or without consolidation whole brain radiotherapy (WBRT). As WBRT carries a substantial risk for cognitive impairment, alternative consolidation treatments have been used to reduce neurotoxicity, including reduced-dose WBRT (rdWBRT) or high-dose chemotherapy with autologous stem cell transplant (HDC-ASCT). In this study, we characterized cognitive functions in PCNSL patients achieving long-term remission following rdWBRT or HDC-ASCT.
Keywords:
- Autologous stem-cell transplantation
- Cancer research
- Induction chemotherapy
- Primary central nervous system lymphoma
- Stem cell
- Methotrexate
- Oncology
- Radiation therapy
- Medicine
- Internal medicine
- Chemotherapy
- Standard treatment
- Effects of sleep deprivation on cognitive performance
- Executive functions
- Neurology
- Pathology
- Correction
- Source
- Cite
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