1,3-Oxazino[4,5-b]indole-2,4-(1H,9H)-diones and 5,6-dimethylpyrrolo-[2,3-d]-1,3-oxazin-2,4-(1H,7H)-diones as serine protease inhibitors
1994
Abstract 9-Substituted-1,3-oxazino[4,5-b]indole-2,4-(1 H ,9 H )-diones and 7-substituted-5,6-dimethylpyrrolo[2,3-d]-1,3-oxazin-2,4-(1 H ,7 H )-diones are synthesized from indolo- or pyrrolo-β-enamino t -butyl esters in moderate yield. Certain compounds are found to inhibit human leukocyte elastase (HLE) and chymotrypsin selectively.
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