Diagnosis and Chemotherapy of Human Trypanosomiasis and Vector Ecology of Rift Valley Fever and Congo-Crimean Hemorrhagic Fever in Kenya

Abstract : This activity is Principally centered around work with the KETRI vervet Model and the Alupe Human Sleeping Sickness Referral Hospital at Busia. Over the last ten years, KETRI has been able to develop a primate model that closely mimics late stage human sleeping sickness. Application of this model for development and refinement of diagnostic and chemotherapeutic regimens is now in progress. By mid-term of this project, five potential compounds from Walter Reed Army Institute had been screened. Three of the compounds proved to have an efficacy that merits further investigation. Although no funds were specifically allocated for combination therapy the project reviewers recommended that the synergism reported between suramin and other drugs by other workers be investigated in the KETRI Vervet model. This work has started especially using DFMO and a combination of other drugs.... RA I, Volunteers, Hemorrhagic fever, Vectors, Trypanosomiasis, Rift valley fever, Lab animals, Monkey.