Human trypanosomiasis is a cutaneous condition caused by several species of trypanosomes, with skin manifestations usually being observed in the earlier stages of the disease as evanescent erythema, erythema multiforme, and edema, especially angioedema.:428 Human trypanosomiasis is a cutaneous condition caused by several species of trypanosomes, with skin manifestations usually being observed in the earlier stages of the disease as evanescent erythema, erythema multiforme, and edema, especially angioedema.:428