Abstract P498: Redox Regulation of Vascular Smooth Muscle cGMP Signaling and Blood Pressure by Cytochrome B5 Reductase 3

Oxidized soluble guanylate cyclase (sGC) heme iron (Fe3+) is desensitized to nitric oxide (NO) and attenuates cGMP production needed for downstream activation of PKG-dependent signaling and vasodil...