Inhibitors of Platelet Integrin αllbβ3

Continued examination of substituted 5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-ones as inhibitors of the platelet αIIbβ3 receptor, resulted in the optimized agent ML165 (CID-44820665, NCGC00183896-01). This agent represents the most potent non-RGC mimetic inhibitor of the αIIbβ3 receptor, and due to its unique biding mechanism, offers a novel tool to study this receptor. Appropriate aqueous solubility and stability was found for this agent.