Discovery of new piperidine amide triazolobenzodiazepinones as intestinal-selective CCK1 receptor agonists
2012
Abstract New cholecystokinin-1 receptor (CCK1R) agonist ‘triggers’ were identified using iterative library synthesis. Structural activity relationship studies led to the discovery of compound 10e , a potent CCK1R agonist that demonstrated robust weight loss in a diet-induced obese rat model with very low systemic exposure. Pharmacokinetic data suggest that efficacy is primarily driven through activation of CCK1R’s located within the intestinal wall.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
21
References
10
Citations
NaN
KQI