Synthesis of (4′R)-Azido-(2′R)-2′-Deoxy-2′-C-Methyluridine and Its Esters by Direct Iodide Displacement

The synthesis of an anti-infective nucleoside intermediate was accomplished through direct iodine displacement at C-5′ by a tetrabutylammonium carboxylate. This approach constitutes a more efficient alternative to the traditional oxidative displacement.