A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies

Carsten Bahr,Lisa von Paleske,Veli Vural Uslu,Silvia Remeseiro,Naoya Takayama,Stanley W.K. Ng,Alex Murison,Katja Langenfeld,Massimo Petretich,Roberta Scognamiglio,Petra Zeisberger,Amelie S. Benk,Ido Amit,Peter W. Zandstra,Mathieu Lupien,John E. Dick,Andreas Trumpp,François Spitz

A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies

2018

Carsten Bahr
Lisa von Paleske
Veli Vural Uslu
Silvia Remeseiro
Naoya Takayama
Stanley W.K. Ng
Alex Murison
Katja Langenfeld
Massimo Petretich
Roberta Scognamiglio
Petra Zeisberger
Amelie S. Benk
Ido Amit
Peter W. Zandstra
Mathieu Lupien
John E. Dick
Andreas Trumpp
François Spitz

A blood enhancer cluster forms a highly combinatorial system that allows precise control of Myc expression across normal and leukaemic haematopoietic stem-cell hierarchies.

Keywords:

Stem cell
Enhancer
Cancer research
Haematopoiesis
Biology
Cell biology
RUNX1
Progenitor cell
Transcription factor
Chromatin
Gene expression

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