Clinical management of thyroid nodules with indeterminate cytology: our institutional experience using sIapeC cytological criteria and v600-braf test

. The BRAF gene encodes a serine/threonine specific protein kinase, an enzyme that plays a key-role in regulating the MAP-kinase signalling pathway, which affects cell di-vision, differentiation and secretion. The most common BRAF mutation is V600E, the replacement of a thymine with an adenine on the 1796 nucleotide, thereby obtain-ing a substitution Glu for Val at position 600. The RNA transcribed behaves like an oncogene. BRAF V600E is the most common genetic aberration in adult papillary thyroid cancer, found in 29-69% of cases, and is often associated with more aggressive behaviour and less dif-ferentiated tumours