COMPARATIVE STUDY OF THE DIFFERENTIATION POTENTIAL OF RAT BONE MARROW MESENCHYMAL STEM CELLS AND RAT MUSCLE-DERIVED STEM CELLS
2013
We present a comparative study of the plasticity of rat bone marrow
mesenchymal stem cells (MSCs) and rat muscle-derived stem cells (MDSCs). The
study was performed on two cell populations that were isolated by aspiration
from the femur bone marrow and gastrocnemius muscle biopsy of 6-week-old
albino rats. Both cell populations were exposed to identical stimulation
conditions. The cells were capable of undergoing osteogenic, chondrogenic,
adipogenic and epithelial differentiation, as shown by histochemistry and
immunostaining techniques. The MDSC population showed behavior and
characteristics similar to the bone marrow MSC population; however, the
osteogenic and adipogenic potential was more reduced compared to MSCs. Our
results indicate a positive expression of E cadherin and Cytokeratin 10 after
28 days under epithelial stimulation, suggesting a potential use for
gastrocnemius muscle MDSCs as a promising source for regenerative therapies,
including re-epithelialization and skin regeneration.
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