Clinical implications of G-CSF receptor mutations

2. The physiology of mutated G-CSF receptors . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 2.1. Frequency of G-CSF receptor point mutations in chronic neutropenia . . . . . . . . . . 2 2.2. The function of mutated G-CSF receptors in transfected cell lines . . . . . . . . . . . . 2 2.3. In vivo data on G-CSF receptor point mutations in patients . . . . . . . . . . . . . . . 3 2.4. Mutated G-CSF receptors and leukemogenesis . . . . . . . . . . . . . . . . . . . . . . . . 4