Association of thymidylate synthase (TYMS) polymorphism with adverse events (AEs) of 5-FU/capecitabine (CAP) in pts with GI cancers.

e14561Background: TYMS catalyzes methylation of dUMP to dTMP. As the sole de novo source of thymidylate in the cell it is an important target for 5-FU/CAP. Overexpression of TYMS has been linked to...