iPSCs: From Bench to Clinical Bed

Induced pluripotent stem cells (iPSC) have been acknowledged as a milestone in the field of stem cell biology and regenerative medicine, providing an excellent tool to tackle fundamental biological issues regarding reproduction, regeneration, and (de)differentiation at genetic and epigenetic levels, and the valuable cell sources for tissue regeneration, human disease modeling, and drug discovery. Furthermore, iPSC generation with patient-specific somatic cells holds great promise for autologous cell replacement therapy and organ transplantations. Thus, the iPSCs have attracted significant attentions in generation methods, mechanisms of reprogramming, and therapeutical applications. Given a body of achievements in iPSC generation methodology, mechanisms, and clinical application, it is of significance to publish a special issue focused on the topic of iPSCs (from bench to clinical bed). In this special issue, research and review articles are collected, covering the advances in the areas of iPSC generation strategies, molecular mechanisms for reprogramming, iPSC models for human diseases, cell therapy, organ generation, and transplantation.