Impact of macular lesions in acute stage of Vogt-Koyanagi-Harada syndrome on visual prognosis

Objective To investigate the impact of the detachment and edema of acute macular retinal nerve fiber layer on visual prognosis in patients with Vogt-Koyanagi-Harada syndrome(VKHs).Methods A retrospective analysis was performed on the macular lesions,visual distribution before and after treatment of 74 VKHs of the first attack patients (108 eyes) whom visited Zhongshan Ophthalmic Center,Sun Yat-sen University from December 2006 to January 2009.The post-treatment vision of the patients with or without macular detachment and edema were compared.Results There were 53 patients with macular detachment and edema (71.62％),and 21 patients without (28.38％) in 74 VKHs patients.The incipient hypopsia of the VKHs patients with macular detachment and edema was mainly distributed over 0.01 to ＜0.5,and 0.1 to ＜0.5 in patients without macular detachment and edema.The proportions of visual acuity ≥1.0 after treatment were 86.79％ (46/53) and 100％ (21/21) in VKHs patients of acute phase with or without macula detachment and edema (P＞0.05).Conclusion With timely and effectively treatment,the visual prognosis is not affected by the acute macular lesions in VKHs patients. Key words: Vogt-Koyanagi-Harada syndrome ;  Macular edema;  Prognosis