PKA-induced dimerization of the RhoGAP DLC1 promotes its inhibition of tumorigenesis and metastasis

Deleted in Liver Cancer 1 (DLC1) is a tumour suppressor that inhibits metastasis by inactivating the small GTPase, RhoA. Here the authors reveal that DLC1 function is stimulated by protein kinase A, which induces phosphorylation-dependent DLC1 dimerization.