A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models.

Xufen Yu,Dongxu Li,Jithesh Kottur,Yudao Shen,Huen Suk Kim,Kwang-su Park,Yi-Hsuan Tsai,Weida Gong,Jun Wang,Kyogo Suzuki,Joel S. Parker,Laura E. Herring,H. Ümit Kaniskan,Ling Cai,Rinku Jain,Jing Liu,Aneel K. Aggarwal,Gang Greg Wang,Jian Jin

A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models.

2021

Xufen Yu
Dongxu Li
Jithesh Kottur
Yudao Shen
Huen Suk Kim
Kwang-su Park
Yi-Hsuan Tsai
Weida Gong
Jun Wang
Kyogo Suzuki
Joel S. Parker
Laura E. Herring
H. Ümit Kaniskan
Ling Cai
Rinku Jain
Jing Liu
Aneel K. Aggarwal
Gang Greg Wang
Jian Jin

Interactions between WD40 repeat domain protein 5 (WDR5) and its various partners such as mixed lineage leukemia (MLL) and c-MYC are essential for sustaining oncogenesis in human cancers. However, ...

Keywords:

WDR5
Cancer research
Myeloid leukemia
in patient
Medicine
Text mining

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